Estudios clínicos
Tecnología Nano-Pulse Stimulation™ (NPS™)
Pulse Biosciences apoya la investigación clínica dedicada al desarrollo de evidencia científica que respalde las mejoras en el uso de la tecnología NPS. A continuación, se proporcionan publicaciones científicas, presentaciones, resúmenes y pósteres con fines educativos sobre el uso de la tecnología NPS en el entorno clínico.
El sistema CellFX® utiliza la tecnología Nano-Pulse Stimulation (NPS) y cuenta con el marcado CE aprobado con indicación de uso en tratamientos dermatológicos que requieren ablación y rejuvenecimiento de la piel para la reducción, eliminación o remisión de lesiones benignas de tipo celular. La indicación de CellFX es la reducción, eliminación o remisión de lesiones benignas de tipo celular, incluidas la hiperplasia sebácea, las verrugas cutáneas no genitales y la queratosis seborreica.
Publicaciones científicas
Estas publicaciones científicas revisadas son para la educación médica sobre el perfil de seguridad y eficacia de la tecnología NPS.
Airborne particulate concentration during non-thermal nano-pulse stimulation wart clearance is negligible compared to thermal modalities
Ross E, Newman J, Ravichandran J, Nuccitelli R. Lasers in Surgery and Medicine, 2021.
Safety and Efficacy of Nano-Pulse Stimulation Treatment of Non-Genital, Cutaneous Warts (Verrucae)
Nuccitelli R, LaTowsky B, Lain E, et al. Lasers in Surgery and Medicine, 2021.
A Dose-Response Study of Nanosecond Electric Energy Pulses on Facial Skin.
Newman J, Jauregui L, Knape WA, et al. Journal of Cosmetic and Laser Therapy, 2020.
Safety and Efficacy of Nanosecond Pulsed Electric Field Treatment of Sebaceous Gland Hyperplasia.
Munavalli G, Zelickson B, Selim M, et al. Dermatologic Surgery, 2020.
Nano‐Pulse Stimulation Induces Changes in the Intracellular Organelles in Rat Liver Tumors Treated In Situ.
Nuccitelli R, McDaniel A, Connolly R, Zelickson B, Hartman H. Lasers in Surgery and Medicine, 2020.
Safety and Efficacy of Nanosecond Pulsed Electric Field Treatment of Seborrheic Keratoses.
Hruza G, Zelickson B, Selim M, et al. Dermatologic Surgery, 2020.
Nano-Pulse Stimulation Therapy for the Treatment of Skin Lesions.
Nuccitelli R. Bioelectricity, 2019.
A Dose-Response Study of a Novel Method of Selective Tissue Modification of Cellular Structures in the Skin With Nanosecond Pulsed Electric Fields.
Kaufman D, Martinez M, Jauregui L, et al. Lasers in Surgery and Medicine, 2019.
Nano-Pulse Stimulation Induces Immunogenic Cell Death in Human Papillomavirus-Transformed Tumors and Initiates an Adaptive Immune Response.
Skeate JG, Da Silva DM, Chavez-Juan E, Anand S, Nuccitelli R, Kast WM. PLOS ONE, 2018.
Nano-Pulse Stimulation Is a Physical Modality That Can Trigger Immunogenic Tumor Cell Death.
Nuccitelli R, McDaniel A, Anand S, et al. Journal for ImmunoTherapy of Cancer, 2017.
First-in-Human Trial of Nanoelectroablation Therapy for Basal Cell Carcinoma: Proof of Method.
Nuccitelli R, Wood R, Kreis M, et al. Experimental Dermatology, 2014.
Non-Thermal Nanoelectroablation of UV-Induced Murine Melanomas Stimulates an Immune Response.
Nuccitelli R, Tran K, Lui K, et al. Pigment Cell Melanoma Research, 2012.
Presentaciones científicas y en póster
Los líderes de opinión en dermatología y cirugía plástica con quienes Pulse Biosciences colaboró para realizar estudios clínicos en el desarrollo de la tecnología NPS para la comunidad científica y médica generaron la siguiente lista de presentaciones y publicaciones presentadas en póster.
ASLMS
Multi-Center Study of Nano-Pulse Stimulation (NPS) Technology for the Treatment of Moderate-to-Severe Acne Vulgaris of the Back: A Feasibility Study (Interim Results).
ASLMS
A Prospective, Non-Randomized, Multicenter Pivotal Study of Nano-Pulse Stimulation (NPS) for Treatment of Cutaneous Non-Genital Warts.
ASLMS
A Feasibility Study for the Treatment of Moderate to Severe Acne Vulgaris of the Back Using Nano-Pulse Stimulation Energy.
ASLMS
A Dose-Response Study of a Novel Non-Thermal Method of Selectively Modifying Cellular Structures in Skin with Low Energy Nanosecond Electrical Stimulation
ASDS
Histologic and Cinical Comparison of Scar Cosmesis Using Nano-Pulse Stimulation vs Traditional Surgical Treatments of Basal Cell Carcinoma.
ASDS
Lower Energy Settings with Nano-Pulse Stimulation (NPS) Procedure to Treat Sebaceous Hyperplasia Yield High Efficacy and Superior Skin Recovery (Interim Results).
ASDS
A Feasibility Study of Non-Thermal Nano-Pulse Stimulation (NPS) Technology for Treating Common Nevi.
ASDS
Histology of Cellular Sebaceous Glands After Nano-Pulse Stimulation Procedure Demonstrates Mechanism for High Sebaceous Hyperplasia Clearance Rate in Clinical Use.
MOA Symposium
Multi-Center Study of Nano-Pulse Stimulation (NPS) Technology for the Treatment of Moderate-to-Severe Acne Vulgaris of the Back: A Feasibility Study (Interim Results).
SCALE
First Clinical Use of Non-Thermal Nano-Pulse Stimulation Treatment to Eliminate Seborrheic Keratosis Lesions.
ASLMS
A First Human Feasibility Study of Nano-Pulse Stimulation (NPS) to Evaluate the Potential Elimination of a Biopsy-Confirmed Nodular or Superficial BCC in a Short-Term Treat and Resect Study Design
ASLMS
Nano-Pulse Stimulation (NPS) Technology.
ASLMS
Nano-Pulse Stimulation Technology.
IMCAS
Aesthetic Trends: Nano-Pulse Stimulation Technology.
ODAC
A Dose-Ranging, Multi-Center Pivotal Study Using the Nano-Pulse Stimulation Procedure for Sebaceous Hyperplasia.
Maui Derm
Histologic and Cinical Comparison of Scar Cosmesis Using Nano-Pulse Stimulation vs Traditional Surgical Treatments of Basal Cell Carcinoma.
Winter Clin Derm
Non-Thermal Nano-Pulse Stimulation (NPS) Technology for Treating Cutaneous, Non-Genital Warts: A Feasibility Study.
ASDS
Safety and Efficacy of Nano-Pulse Stimulation in the Treatment of Patients with Sebaceous Hyperplasia.
ASDS
Nano-Pulse Stimulation Technology (What’s New in Dermatologic Surgery).
ASDS
High Amplitude Electromagnetic Fields – A New Player in Dermatology.
Harvard
Nano-Pulse Stimulation (NPS) Dose-Titration Study for the Treatment of Sebaceous Hyperplasia – A Multi-Center Pivotal Study.
Controversies & Conversations
A Multicenter, Pivotal Study Using the Nano-Pulse Stimulation Procedure to Treat Sebaceous Hyperplasia Lesions.
Controversies & Conversations
First Clinical Use of Non-Thermal Nano-Pulse Stimulation Technology for Treating Cutaneous, Non-Genital Warts.
Controversies & Conversations
Nano-Pulse Stimulation (NPS) Procedure to Treat Sebaceous Hyperplasia: A Dose-Ranging, Multi-Center, Pivotal Study.
AAD
Safety and Efficacy of NPS in the Treatment of Sebaceous Hyperplasia and Verrucae.
ASLMS
Hot Topics: Nano-Pulse Stimulation.
ASLMS
Nano-Pulse Stimulation Technology.
Maui Derm
Nano-Pulse Stimulation (NPS) Technology for Treating Tattoos and Basal Cell Carcinomas – Initial Observations.
ASDS
First Clinical Use of Non-Thermal Nano-Pulse Stimulation Procedure to Eliminate Sebaceous Hyperplasia Lesions.
ASLMS
High Amplitude, Nanosecond Electrical Pulsing for Warts.
ASLMS
Non-Thermal Nano-Pulse Stimulation (NPS) Procedure for Treating Cutaneous, Non-Genital Warts Shows High Clearance Efficacy with a Single Session (Interim Results).